- Praticien Attaché en Médecine Intensive Réanimation CHR Orléans : 2005
- Assistant Spécialiste en Médecine Intensive Réanimation CHR Orléans : 2005 –2009
- Praticien Hospitalier en Médecine Intensive Réanimation CHR Orléans : 2009 – 2021
- Membre de la société de réanimation en Langue Française (SRLF)
- Membre de l’association des réanimateurs du Centre Ouest (ARCO)
Travaux & collaborations
Travaux : Articles dans les revues internationales avec comité de lecture.
- Journal of Critical Care 2009, 24:575-82
Dopamine therapy in septic shock: Detrimental effect on survival ? - Intensive Care Med 2010 36 : 940-948.
Central venous pressure measurements improve the accuracy of leg raising-induced change in pulse pressure to predict fluid responsiveness. - Critical Care. 2011 Mar 7;15(2):R85.
Respiratory pulse pressure variation fails to predict fluid responsiveness in acute respiratory distress syndrome. - Critical Care. 2011;15(3):R135. Epub 2011 Jun 6
Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study - Anesth Analg. 2012 Sep;115(3):605-10. Epub 2012 Jun 28.
Are central venous lactate and arterial lactate interchangeable? A human retrospective study. - Ann Fr Anesth Reanim. 2012 May;31(5):
Brachial cuff measurements of blood pressure during passive leg raising for fluid responsiveness prediction. - Crit Care. 2014 Nov 4;18(6):587
Clinical relevance of pulse pressure variations for predicting fluid responsiveness in mechanically ventilated intensive care unit patients: the grey zone approach. - Br J Anaesth. 2016 Sep;117(3):341-9.
Predicting arterial blood gas and lactate from central venous blood analysis in critically ill patients: a multicentre, prospective, diagnostic accuracy study. - JAMA. 2018 Jul 24;320(4):368-378
Effect of In-Bed Leg Cycling and Electrical Stimulation of the Quadriceps on Global Muscle Strength in Critically Ill Adults: A Randomized Clinical Trial. - Crit Care Med 2019 Aug;47(8):e623-e629
Glomerular Hyper- and Hypofiltration During Acute Circulatory Failure: Iohexol-Based Gold-Standard Descriptive Study - BMJ Open 2019 Aug 10;9(8):e029798
High-flow nasal oxygen therapy alone or with non-invasive ventilation in immunocompromised patients admitted to ICU for acute hypoxemic respiratory failure: the randomised multicentre controlled FLORALI-IM protocol - Ann Intensive Care 2019 Sep 23;9(1):106.
Nephrotoxic drug burden among 1001 critically ill patients: impact on acute kidney injury - Crit Care Med. 2019 Aug;47(8):e623-e629.
Glomerular Hyper-and Hypofiltration During Acute Circulatory Failure : Iohexol-Based Gold-Standard Descriptive Study
Collaborateurs dans d’autres études Médicales
- N Engl J Med 2013 Jun 6;368(23):2159-68.
Guérin C and collaborators, PROSEVA Study Group.
Prone positioning in severe acute respiratory distress syndrome. - JAMA. 2013 Jan 16;309(3):249-56
Reignier J collaborators Clinical Research in Intensive Care and Sepsis (CRICS) Group.
Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial - Intensive Care Med. 2013 May;39(5):872-80.
Vignon P1 and collaborators, Clinical Research in Intensive Care and Sepsis Group (CRICS Group).
Intermittent pneumatic compression to prevent venous thromboembolism in patients with high risk of bleeding hospitalized in intensive care units: the CIREA1 randomized trial. - Crit Care. 2014 Nov 6;18(6):609.
Boulain T and collaborators , Clinical Research in Intensive Care and Sepsis Group.
Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: a prospective multicentre study. - N Engl J Med . 2015 Jun 4;372(23):2185-96.
Frat JP and collaborators , FLORALI Study Group.; REVA Networkeee
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. - Crit Care. 2015 Apr 17;19:174
Legras A and collaborators ARCO and CRICS network.
Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study. - N Engl J Med. 2015 Jun 4;372(23):2185-96.
Frat JP and FLORALI Study Group; REVA Network.
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. - N Engl J Med. 2018 Mar 1;378(9):809-818
Annane D and CRICS-TRIGGERSEP Network.
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock. - Lancet. 2018 Jan 13;391(10116):133-143
Reignier J , Nutrirea-2 collaborators Clinical Research in Intensive Care and Sepsis (CRICS) Group.
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). - N Engl J Med 2018 Mar 1;378(9):809-818
Djillali Annane , CRICS-TRIGGERSEP Network
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock - Engl J Med 2019 Nov 7;381(19):1831-1842
Bruno François et Al , CRICS-TRIGGERSEP Network and the ANTHARTIC Study Group
Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest - N Engl J Med 2020 Jul 16;383(3):240-251.
Bagshaw SM , STARRT-AKI Investigators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group; United Kingdom Critical Care Research Group; Canadian Nephrology Trials Network; Irish Critical Care Trials Group
Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury - JAMA 2020 Oct 6;324(13):1317-1329
Derek C Angus and al
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial - N Engl J Med 2021 Aug 4
REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators;
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 - N Engl J Med. 2021 Apr 22;384(16):1491-1502.
REMAP-CAP Investigators
Interleukin-6 Receptor Antagonists in Critically III Patients with Covid 19